Sebetralstat

Sebetralstat, sold under the brand name Ekterly, is a medication used for the treatment of hereditary angioedema.Sebetralstat is a plasma kallikrein inhibitor that suppresses the activation of the positive feedback mechanism of the kallikrein-kinin system, thereby reducing factor XIIa and additional plasma kallikrein production. By inhibiting plasma kallikrein, sebetralstat reduces the production of bradykinin, thereby halting the progression of hereditary angioedema attacks. It is taken by mouth.